ML133 hydrochloride | Kir2.1 inhibitor | Probechem Biochemicals

Chemical Structure : ML133 hydrochloride

CAS No.: 1222781-70-5

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ML133 hydrochloride (CID781301 hydrochloride)

货号: PC-62357Not For Human Use, Lab Use Only.

ML133 (CID781301) is a potent, selective K(ir)2.1 potassium channel with IC50 of 1.8 uM at pH 7.4 and 290 nM at pH 8.5, respectively.

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10 mg	￥780	In stock
25 mg	￥1180	In stock
50 mg	￥1880	In stock
100 mg	￥2880	In stock
200 mg		Get quote

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生物&药学活性

ML133 (CID781301) hydrochlorideis a potent, selective K(ir)2.1 potassium channel with IC50 of 1.8 uM at pH 7.4 and 290 nM at pH 8.5, respectively.
ML133 exhibits little selectivity against other members of Kir2.x family channels, but displays excellent selectivity over K(ir)1.1, K(ir)4.1 and K(ir)7.1.
ML133 dramatically reduces Ca2+ influx through Ca2+-release-activated Ca2+ (CRAC) channels.

物理化学性质&存储条件

分子量	313.825
分子式	C19H20ClNO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride

参考文献

1. Wang HR, et al. ACS Chem Biol. 2011 Aug 19;6(8):845-56.

2. Wu M, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

3. Ford NC, et al. Neuroscience. 2016 Dec 17;339:502-510.

ML133 hydrochloride (CID781301 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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ML133 hydrochloride (CID781301 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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