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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-ML133
ML133

Chemical Structure : ML133

CAS No.: 185669-79-8

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ML133 (CID781301)

货号: PC-62358Not For Human Use, Lab Use Only.

ML133 (CID781301) is a potent, selective K(ir)2.1 potassium channel with IC50 of 1.8 uM at pH 7.4 and 290 nM at pH 8.5, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML133 (CID781301) is a potent, selective K(ir)2.1 potassium channel inhibitor with IC50 of 1.8 uM at pH 7.4 and 290 nM at pH 8.5, respectively.
ML133exhibits little selectivity against other members of Kir2.x family channels, but displays excellent selectivity over K(ir)1.1, K(ir)4.1 and K(ir)7.1.
ML133 dramatically reduces Ca2+ influx through Ca2+-release-activated Ca2+ (CRAC) channels.

物理化学性质&存储条件

分子量 277.367
分子式 C19H19NO
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine

参考文献

1. Wang HR, et al. ACS Chem Biol. 2011 Aug 19;6(8):845-56.

2. Wu M, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

3. Ford NC, et al. Neuroscience. 2016 Dec 17;339:502-510.

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