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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-ML116
ML116

Chemical Structure : ML116

CAS No.: 744270-00-6

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ML116 (ML 116;ML-116)

货号: PC-60659Not For Human Use, Lab Use Only.

ML116 is a selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM).

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5 mg ￥2780 In stock
10 mg ￥4280 In stock
25 mg ￥7280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML116 is a selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM).
ML116 inhibits transcription of the STAT3-regulated gene BCL3, slectively induces loss of viability of breast cancer cell lines such as MDA-MB-468 cells.

物理化学性质&存储条件

分子量 309.431
分子式 C18H19N3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-benzyl-1-{thieno[2,3-d]pyrimidin-4-yl}piperidine

参考文献

1. Assi HH, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):458-69.

2. Madoux F, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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