ML115 | MMP-2 inhibitor | Probechem Biochemicals

Chemical Structure : ML115

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ML115 (ML 115)

货号: PC-62732Not For Human Use, Lab Use Only.

ML115 is a novel bone-seeking, bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9.

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生物&药学活性

ML115 is a novel bone-seeking, bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9.
ML115 affects the viability of breast cancer cell lines and osteoclast precursors, but not osteoblasts in vitro, significantly reduces tumor growth and tumor-associated bone destruction in bone metastatic models (PyMT-R221A and 4T1).
ML115 also decreases multiple myeloma burden and protect against cancer-induced osteolysis, specifically inhibits in the multiple myeloma-bone microenvironment.

物理化学性质&存储条件

分子量	407.27
分子式	C13H15NO8P2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(([1,1'-biphenyl]-4-sulfonamido)methylene)bis(phosphonic acid)

参考文献

1. Tauro M, et al. Mol Cancer Ther. 2017 Mar;16(3):494-505.

2. Shay G, et al. Oncotarget. 2017 Jun 27;8(26):41827-41840.

3. Rubino MT, et al. ChemMedChem. 2011 Jul 4;6(7):1258-68.

ML115 (ML 115)

生物&药学活性

物理化学性质&存储条件

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ML115 (ML 115)

生物&药学活性

物理化学性质&存储条件

参考文献

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