ML104 |CAS:1314124-95-2 Probechem Biochemicals

Chemical Structure : ML104

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ML104 (ML 104, ML-104)

货号: PC-62731Not For Human Use, Lab Use Only.

ML104 is a "bone-seeking" bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9.

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生物&药学活性

ML104 is a "bone-seeking" bisphosphonate based MMP-2 specific inhibitor (BMMPI), spares the activity of other MMPs including MMP-9.
ML104 affects the viability of breast cancer cell lines and osteoclast precursors, but not osteoblasts in vitro, significantly reduces tumor growth and tumor-associated bone destruction in bone metastatic models (PyMT-R221A and 4T1).
ML104 also decreases multiple myeloma burden and protect against cancer-induced osteolysis, specifically inhibits in the multiple myeloma-bone microenvironment.

物理化学性质&存储条件

分子量	441.712
分子式	C13H14ClNO8P2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(((4'-chloro-[1,1'-biphenyl])-4-sulfonamido)methylene)bis(phosphonic acid)

参考文献

1. Tauro M, et al. Mol Cancer Ther. 2017 Mar;16(3):494-505.

2. Shay G, et al. Oncotarget. 2017 Jun 27;8(26):41827-41840.

3. Rubino MT, et al. ChemMedChem. 2011 Jul 4;6(7):1258-68.

ML104 (ML 104, ML-104)

生物&药学活性

物理化学性质&存储条件

参考文献

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ML104 (ML 104, ML-104)

生物&药学活性

物理化学性质&存储条件

参考文献

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