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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-ML-SI3
ML-SI3

Chemical Structure : ML-SI3

CAS No.: 2563870-87-9

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ML-SI3 (Mucolipin-specific synthetic inhibitor 3)

货号: PC-73026Not For Human Use, Lab Use Only.

ML-SI3 (Mucolipin-specific synthetic inhibitor 3) is a synthetic antagonist of transient receptor potential mucolipin 1 (TRPML1), prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ML-SI3 (Mucolipin-specific synthetic inhibitor 3) is a synthetic antagonist of transient receptor potential mucolipin 1 (TRPML1), prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy.
    The TRPML1 inhibitor ML-SI3 binds the same cavity as its agonist ML-SA1.
    ML-SI3 competes with ML-SA1 to block the channel activity.
    ML-SI3 blocks TRPML1 channel activation yet does not inhibit PI(3,5)P2-dependent activation of the channel.
    Transient receptor potential mucolipin 1 (TRPML1) regulates lysosomal calcium signaling, lipid trafficking, and autophagy-related processes.

    物理化学性质&存储条件

    分子量 429.579
    分子式 C23H31N3O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((1S,2S)-2-(4-(2-methoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide

    参考文献

    1. Philip Schmiege, et al. Structure. 2021 Nov 4;29(11):1295-1302.e3.

    2. Li D, et al. Autophagy. 2021 Apr;17(4):872-887.

    3. Leser C, et al. Eur J Med Chem. 2021 Jan 15;210:112966.

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