ML-SA5 | TRPML1 agonist | Probechem Biochemicals

Chemical Structure : ML-SA5

CAS No.: 2418670-70-7

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ML-SA5 (TRPML1 agonist ML-SA5)

货号: PC-72043Not For Human Use, Lab Use Only.

ML-SA5 (TRPML1 agonist ML-SA5) is a potent, small molecule agonist of transient receptor potential mucolipin 1 (TRPML1/MCOLN1/ML1), dose-dependently activated whole-endolysosomal ML1 currents in DMD myoblasts with EC50 of 285±144 nM.

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生物&药学活性

ML-SA5 (TRPML1 agonist ML-SA5) is a potent, small molecule agonist of transient receptor potential mucolipin 1 (TRPML1/MCOLN1/ML1), dose-dependently activated whole-endolysosomal ML1 currents in DMD myoblasts with EC50 of 285±144 nM.
ML-SA5–induced lysosomal Ca2+ release, measured with GCaMP3 imaging, in primary myotubes isolated from ML1MCK mice.
ML-SA5 ML1 agonist ML-SA5 ameliorate muscular dystrophies, facilitates sarcolemma repair to reduce muscle damage, activates TFEB to correct lysosomal insufficiency in mdx mice.

物理化学性质&存储条件

分子量	457.988
分子式	C19H24ClN3O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,4-Benzenedisulfonamide, N4-[3-chloro-2-(1-piperidinyl)phenyl]-N1,N1-dimethyl-

参考文献

1. Lu Yu, et al. Sci Adv. 2020 Feb 7;6(6):eaaz2736.

ML-SA5 (TRPML1 agonist ML-SA5)

生物&药学活性

物理化学性质&存储条件

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ML-SA5 (TRPML1 agonist ML-SA5)

生物&药学活性

物理化学性质&存储条件

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