ML-SA1 | TRPML1 agonist | Probechem Biochemicals

Chemical Structure : ML-SA1

CAS No.: 332382-54-4

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ML-SA1 (Mucolipin-specific synthetic agonist 1)

货号: PC-73025Not For Human Use, Lab Use Only.

ML-SA1 (Mucolipin-specific synthetic agonist 1) is a potent synthetic agonist for TRPML1.

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10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
250 mg		Get quote

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生物&药学活性

ML-SA1 (Mucolipin-specific synthetic agonist 1) is a potent synthetic agonist for TRPML1.
ML-SA1 induces significant [Ca2+]cyt increases in HEK293 cells stably- or transiently-expressing ML1-4A.
ML-SA1 targets all three TRPMLs, the expression levels of TRPML2 and TRPML3 are very low, and TRPML1 is the predominant lysosomal TRPML channel.
ML-SA1 induces TRPML1-mediated Ca2+ release from lysosomes.
ML-SA1 and TRPML1 overexpression rescue the trafficking defects and reduce cholesterol accumulation in NPC cells.

物理化学性质&存储条件

分子量	362.429
分子式	C22H22N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione

参考文献

1. Dongbiao Shen, et al. Nat Commun. 2012 Mar 13;3:731.

ML-SA1 (Mucolipin-specific synthetic agonist 1)

生物&药学活性

物理化学性质&存储条件

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ML-SA1 (Mucolipin-specific synthetic agonist 1)

生物&药学活性

物理化学性质&存储条件

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