ML-9 free base | MLCK inhibitor | Probechem Biochemicals

Chemical Structure : ML-9 free base

加入收藏

ML-9 free base (MLCK inhibitor)

货号: PC-23162Not For Human Use, Lab Use Only.

ML-9 is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ML-9 is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines.
ML-9 also inhibits PKA and PKC with Ki of 32 uM and 54 uM.
ML-9 inhibits STIM1-plasma membrane interactions and inhibits TRPC6 channels via a mechanism independent of inhibition of MLCK activity.

物理化学性质&存储条件

分子量	416.28
分子式	C15H17IN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((5-iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane

参考文献

1. Shi J, et al. Br J Pharmacol. 2007 Sep;152(1):122-31.

2. Várnai P, et al. Trends Pharmacol Sci. 2009 Mar;30(3):118-28.

3. Ito S, et al. Eur J Pharmacol. 2004 Feb 23;486(3):325-33.