ML-9 | MLCK inhibitor | Probechem Biochemicals

Chemical Structure : ML-9

CAS No.: 105637-50-1

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ML-9 (MLCK inhibitor ML-9)

货号: PC-62887Not For Human Use, Lab Use Only.

ML-9 is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines.

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10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1480	In stock
100 mg	￥2380	In stock
250 mg		Get quote

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生物&药学活性

ML-9 is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines.
ML-9 also inhibits PKA and PKC with Ki of 32 uM and 54 uM.
ML-9 inhibits STIM1-plasma membrane interactions and inhibits TRPC6 channels via a mechanism independent of inhibition of MLCK activity.

物理化学性质&存储条件

分子量	361.281
分子式	C15H18Cl2N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-1H-1,4-diazepine, monohydrochloride

参考文献

1. Shi J, et al. Br J Pharmacol. 2007 Sep;152(1):122-31.

2. Várnai P, et al. Trends Pharmacol Sci. 2009 Mar;30(3):118-28.

3. Ito S, et al. Eur J Pharmacol. 2004 Feb 23;486(3):325-33.

ML-9 (MLCK inhibitor ML-9)

生物&药学活性

物理化学性质&存储条件

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ML-9 (MLCK inhibitor ML-9)

生物&药学活性

物理化学性质&存储条件

参考文献

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