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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-MKT-077
MKT-077

Chemical Structure : MKT-077

CAS No.: 147366-41-4

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MKT-077 (FJ-776, MKT077)

货号: PC-62565Not For Human Use, Lab Use Only.

MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity, binds to Hsp70 family member, mortalin (mot-2), and abrogates its interactions with p53.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity, binds to Hsp70 family member, mortalin (mot-2), and abrogates its interactions with p53.
MKT-077 induces release of wild-type p53 from cytoplasmically sequestered p53-mot-2 complexes and rescued its transcriptional activation function.
MKT-077 also is a potent telomerase inhibitor with IC50 of 5 uM.

物理化学性质&存储条件

分子量 432
分子式 C21H22ClN3OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (9CI)

参考文献

1. Koya K, et al. Cancer Res. 1996 Feb 1;56(3):538-43.

2. Wadhwa R, et al. Cancer Res. 2000 Dec 15;60(24):6818-21.

3. Naasani I, et al. Cancer Res. 1999 Aug 15;59(16):4004-11.

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