MKK7-COV-3 |CAS 2283355-54-2 Probechem Biochemicals

Chemical Structure : MKK7-COV-3

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MKK7-COV-3 (MKK7 Covalent inhibitor 3)

货号: PC-35803Not For Human Use, Lab Use Only.

MKK7-COV-3 (MKK7 Covalent inhibitor 3) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 5 nM, displays >1,000-fold selectivity over MKK4 (IC50=7.81 uM).

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生物&药学活性

MKK7-COV-3 (MKK7 Covalent inhibitor 3) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 5 nM, displays >1,000-fold selectivity over MKK4 (IC50=7.81 uM).
MKK7-COV-3 shows EC50 of 1.3 uM for reduction of p-JNK in ICW assays in Beas2B cell line, without effect on p-ERK levels at 10 uM.
MKK7-COV-3 displays remarkable selectivity against a kinome panel of 76 kinases, with very few kinases inhibited by more than 75% at 1 uM: Aurora kinase B, LRRK2, and MKK4, as well as FLT3。
MKK7-COV-3 inhibits 60% of the CD86+ response in primary mouse B cells in response to LPS stimulation (10 μM, 2 hr pre-incubation).

物理化学性质&存储条件

分子量	277.327
分子式	C17H15N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(6-methyl-1H-indazol-3-yl)phenyl)acrylamide

参考文献

1. Shraga A, et al. Cell Chem Biol. 2018 Oct 24. pii: S2451-9456(18)30344-1.

MKK7-COV-3 (MKK7 Covalent inhibitor 3)

生物&药学活性

物理化学性质&存储条件

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MKK7-COV-3 (MKK7 Covalent inhibitor 3)

生物&药学活性

物理化学性质&存储条件

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