MKK3 modulator (R)-48

Chemical Structure : MKK3 modulator (R)-48

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货号: PC-28780Not For Human Use, Lab Use Only.

MKK3 modulator (R)-48 is a highly potent, selective, orally bioavailable, non-ATP-competitive MKK3 allosteric modulator with SPR KD of 3.35 nM, exhibits potent TNF-α inhibitory activity with IC50 of 38 nM in RAW264.7 cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MKK3 modulator (R)-48 is a highly potent, selective, orally bioavailable, non-ATP-competitive MKK3 allosteric modulator with SPR KD of 3.35 nM, exhibits potent TNF-α inhibitory activity with IC50 of 38 nM in RAW264.7 cells.
MKK3 modulator (R)-48 selectively targeting and suppressing the TAK1/MKK3/p38 signaling cascade in RAW264.7 cells.
MKK3 modulator (R)-48 (3 mg/kg/day) demonstrated robust therapeutic efficacy on proinflammatory response in DSS-induced acute UC mice.
(R)-48 treatment (1 mg/kg/d and 3 mg/kg/d) ameliorated the symptoms of TNBS-induced experimental colitis in mouse.

物理化学性质&存储条件

分子量	411.45
分子式	C23H25NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(4-(7-Methoxy-5-(2-methoxyethoxy)-3-oxo-2,3-dihydro-1H-inden-1-yl)phenyl)morpholin-3-one

参考文献

1. Kou B, et al. J Med Chem. 2026 Nov 12;69(21):25889-25913.