MKC8866 | IRE1 inhibitor | Probechem Biochemicals

Chemical Structure : MKC8866

CAS No.: 1338934-59-0

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MKC8866 (MKC-8866, ORIN1001, IRE1 RNase inhibitor 8866)

货号: PC-62739Not For Human Use, Lab Use Only.

MKC8866 (ORIN1001) is a spectific small molecule inhibitor of mammalian IRE1 RNase activity with IC50 of 0.29 uM.

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

MKC8866 (ORIN1001) is a spectific small molecule inhibitor of mammalian IRE1 RNase activity with IC50 of 0.29 uM.
ORIN1001 (MKC8866) prevents the recombinant IRE1 protein from cleaving the synthetic XBP1 RNA probe, but has no effect on RNase A, RNase L and yeast IRE1 (scIRE1).
ORIN1001 (MKC8866) suppresses growth of patient-derived tumors with high MYC expression.|
ORIN1001 (MKC8866) potently sensitizes the tumors to the apoptotic and proliferation inhibitory effects of chemotherapy in vivo.

物理化学性质&存储条件

分子量	361.35
分子式	C18H19NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde

参考文献

1. Zhao N, et al. J Clin Invest. 2018 Feb 26. pii: 95873.

2. Sanches M, et al. Nat Commun. 2014 Aug 28;5:4202.

3. Logue SE, et al. Nat Commun. 2018 Aug 15;9(1):3267.

MKC8866 (MKC-8866, ORIN1001, IRE1 RNase inhibitor 8866)

生物&药学活性

物理化学性质&存储条件

参考文献

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MKC8866 (MKC-8866, ORIN1001, IRE1 RNase inhibitor 8866)

生物&药学活性

物理化学性质&存储条件

参考文献

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