MKC-733 | 5-HT3 agonist | Probechem Biochemicals

Chemical Structure : MKC-733

CAS No.: 194093-42-0

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MKC-733 (MKC733, Pumosetrag, DDP 733)

货号: PC-61221Not For Human Use, Lab Use Only.

MKC-733 (Pumosetrag, DDP 733) is a potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors.

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10 mg	￥1580	In stock
25 mg	￥2680	In stock
50 mg	￥4880	In stock
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生物&药学活性

MKC-733 (Pumosetrag, DDP 733) is a potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors.
MKC-733 dose dependently stimulates contraction and basal electrolyte secretion in the isolated guinea pig colon, effects that are antagonized by the selective 5-HT3 antagonist ondansetron,.
MKC-733 also accelerates gastric emptying in some animal models.

物理化学性质&存储条件

分子量	39.838
分子式	C15H18ClN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Thieno[3,2-b]pyridine-6-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxo-, monohydrochloride (9CI)

参考文献

1. Coleman NS, et al. Aliment Pharmacol Ther. 2003 Nov 15;18(10):1039-48.

2. Fujita T, et al.

3. Chetty N, et al. Pharmacology. 2008;81(2):104-9.

4. Choung RS, et al. Neurogastroenterol Motil. 2014 Jan;26(1):13-20.

MKC-733 (MKC733, Pumosetrag, DDP 733)

生物&药学活性

物理化学性质&存储条件

参考文献

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MKC-733 (MKC733, Pumosetrag, DDP 733)

生物&药学活性

物理化学性质&存储条件

参考文献

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