MK 8776 |CAS:891494-63-6 Probechem Biochemicals

Chemical Structure : MK 8776

CAS No.: 891494-63-6

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MK 8776 (SCH900776, MK-8776)

货号: PC-62476Not For Human Use, Lab Use Only.

MK 8776 (SCH 900776) is a potent and functionally selective CHK1 inhibitor (IC50=3 nM) with minimal intrinsic antagonistic properties.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg	￥7880	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

MK 8776 (SCH 900776) is a potent and functionally selective CHK1 inhibitor (IC50=3 nM) with minimal intrinsic antagonistic properties.
MK 8776 (SCH 900776) also inhibits CDK2 with IC50 of 160 nM, weak activity for CHK2 and no significant inhibition of cytochrome P450 isoforms.
MK 8776 (SCH 900776) induces dose-dependent suppression of CHK1 pS296 and concomitant accumulation of phospho-RPA signal in U2OS cells.
MK 8776 (SCH 900776) interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce dsDNA breaks and cell death in the A2780 xenograft model.

物理化学性质&存储条件

分子量	376.25
分子式	C15H18BrN7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-pyrazolo[1,5-a]pyrimidin-7-amine

参考文献

1. Guzi TJ, et al. Mol Cancer Ther. 2011 Apr;10(4):591-602.

2. Paruch K, et al. ACS Med Chem Lett. 2010 May 17;1(5):204-8.

3. Bridges KA, et al. Oncotarget. 2016 Nov 1;7(44):71660-71672.

MK 8776 (SCH900776, MK-8776)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK 8776 (SCH900776, MK-8776)

生物&药学活性

物理化学性质&存储条件

参考文献

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