Chemical Structure : MK6-83
CAS No.: 1062271-24-2
货号: PC-21060Not For Human Use, Lab Use Only.
MK6-83 is a specific transient receptor potential mucolipin -1 (TRPML1/MCOLN1) agonist, activates the entire endosomal TRPML1 current in DMD myocytes with EC50 of 285 nM.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥1980 | In stock | |
50 mg | ¥2980 | In stock | |
100 mg | ¥4980 | In stock | |
200 mg | Get quote | ||
1 g | Get quote |
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MK6-83 is a specific transient receptor potential mucolipin -1 (TRPML1/MCOLN1) agonist, activates the entire endosomal TRPML1 current in DMD myocytes with EC50 of 285 nM.
MK6-83 is more potent than ML-SA1.
MK6-83 arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes.
分子量 | 336.47 | |
分子式 | C16H20N2O2S2 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide |
1. Morelli MB, et al. Cancers (Basel). 2019 Apr 12;11(4):525.
2. Jiansong Qi, et al. Autophagy. 2021 Dec;17(12):4401-4422.
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