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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-MK6-83
MK6-83

Chemical Structure : MK6-83

CAS No.: 1062271-24-2

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MK6-83 (MK 6-83)

货号: PC-21060Not For Human Use, Lab Use Only.

MK6-83 is a specific transient receptor potential mucolipin -1 (TRPML1/MCOLN1) agonist, activates the entire endosomal TRPML1 current in DMD myocytes with EC50 of 285 nM.

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5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MK6-83 is a specific transient receptor potential mucolipin -1 (TRPML1/MCOLN1) agonist, activates the entire endosomal TRPML1 current in DMD myocytes with EC50 of 285 nM.
MK6-83 is more potent than ML-SA1.
MK6-83 arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes.

物理化学性质&存储条件

分子量 336.47
分子式 C16H20N2O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide

参考文献

1. Morelli MB, et al. Cancers (Basel). 2019 Apr 12;11(4):525.

2. Jiansong Qi, et al. Autophagy. 2021 Dec;17(12):4401-4422.

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