MK 2206 dihydrochloride |CAS:1032350-13-2 Probechem Biochemicals

Chemical Structure : MK 2206 dihydrochloride

CAS No.: 1032350-13-2

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MK 2206 dihydrochloride (MK-2206 dihydrochloride;MK2206 dihydrochloride)

货号: PC-42551Not For Human Use, Lab Use Only.

MK 2206 dihydrochloride is a potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

MK 2206 dihydrochloride is a potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively.
MK 2206 shows 5-fold less potent against human Akt3 (IC50=65 nM).
MK 2206 synergistically inhibits cell proliferation of human cancer cell lines in combination with erlotinib or lapatinib in vitro.
MK 2206 suppresses the Akt phosphorylation that is induced by carboplatin and gemcitabine.

物理化学性质&存储条件

分子量	480.389
分子式	C25H23Cl2N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO
Chemical Name/SMILES	1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-, hydrochloride (1:2)

参考文献

1. Hirai H, et al. Mol Cancer Ther. 2010 Jul;9(7):1956-67.

2. Cheng Y, et al. Mol Cancer Ther. 2012 Jan;11(1):154-64.

3. Whicker ME, et al. BMC Cancer. 2016 Jul 27;16:550.

MK 2206 dihydrochloride (MK-2206 dihydrochloride;MK2206 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK 2206 dihydrochloride (MK-2206 dihydrochloride;MK2206 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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