MK2-IN-28 |Cas:1355617-50-3 Buy MK2-IN-28 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : MK2-IN-28

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MK2-IN-28

货号: PC-70144Not For Human Use, Lab Use Only.

MK2-IN-28 is a potent and selective, non-ATP competitive, allosteric MAPKAPK2/3 (MK2/3) inhibitor with IC50 of 8 nM for MK2, hTNFα EC50 of 0.31 uM.

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生物&药学活性

MK2-IN-28 is a potent and selective, non-ATP competitive, allosteric MAPKAPK2/3 (MK2/3) inhibitor with IC50 of 8 nM for MK2, hTNFα EC50 of 0.31 uM. MK2-IN-28 inhibits both MK2 and MK3, and has no or little effect on the other kinases.
MK2-IN-28 ameliorates glucose homeostasis by suppressing excessive HGP and enhancing insulin signaling in obese mice.

物理化学性质&存储条件

分子量	569.665
分子式	C35H31N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-cyanophenyl)-N-(2-(4-methoxypyridin-3-yl)benzyl)-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide

参考文献

1. Huang X, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70.

2. Ozcan L, et al. Diabetes. 2015 Oct;64(10):3396-405.

MK2-IN-28

生物&药学活性

物理化学性质&存储条件

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MK2-IN-28

生物&药学活性

物理化学性质&存储条件

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