MK2-IN-1 |CAS:1314118-92-7 Probechem Biochemicals

Chemical Structure : MK2-IN-1

CAS No.: 1314118-92-7

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MK2-IN-1 (MK2 Inhibitor)

货号: PC-43243Not For Human Use, Lab Use Only.

MK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2(MK2) inhibitor with IC50 of 0.11 uM.

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5 mg	￥1880	In stock
10 mg	￥3280	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

MK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2 (MK2) inhibitor with IC50 of 0.11 uM.
MK2-IN-1 shows excellent kinase selectivity against a broad panel of 150 protein kinases at 10 μM with only on exception of CK1γ3 >50 % inhibition.
MK2-IN-1 inhibits pro-inflammatory cytokine secretion from the human THP1 acute monocytic leukemia cell line, causing dose-dependent inhibition of LPS-stimulated TNFα and IL6 secretion.
MK2-IN-1 also dose dependently inhibits IL1β-stimulated MMP13 secretion from the SW1353 chondrosarcoma cell line and human primary chondrocyte cultures.

物理化学性质&存储条件

分子量	472.966
分子式	C27H25ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Furancarboxamide, 5-(4-chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-

参考文献

1. Rao AU, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1068-72.

2. Huang X, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70.

3. Huang X, et al. ACS Med Chem Lett. 2011 Jun 24;2(8):632-7.

MK2-IN-1 (MK2 Inhibitor)

生物&药学活性

物理化学性质&存储条件

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MK2-IN-1 (MK2 Inhibitor)

生物&药学活性

物理化学性质&存储条件

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