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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Aurora Kinase-MK-8745
MK-8745

Chemical Structure : MK-8745

CAS No.: 885325-71-3

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MK-8745 (MK8745)

货号: PC-22868Not For Human Use, Lab Use Only.

MK-8745 (MK8745) a potent, specific Aurora kinase A (Aurora A, AURKA) inhibitor with IC50 of 0.6 nM, induces apoptotic cell death in a p53-dependent manner.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MK-8745 (MK8745) a potent, specific Aurora kinase A (Aurora A, AURKA) inhibitor with IC50 of 0.6 nM, induces apoptotic cell death in a p53-dependent manner.
MK-8745 induces cell cycle arrest at the G2/M phase with accumulation of tetraploid nuclei followed by cell death in non-Hodgkin lymphoma (NHL) cell lines.
Exposure of p53 wild-type cells to MK8745 resulted in the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression.

物理化学性质&存储条件

分子量 431.91
分子式 C20H19ClFN5OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3-Chloro-2-fluorophenyl)[4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-piperazinyl]methanone

参考文献

1. Chowdhury A, et al. Leuk Lymphoma. 2012 Mar;53(3):462-71.

2. Nair JS, et al. Cell Cycle. 2012 Feb 15;11(4):807-17.

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