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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-MK-8617
MK-8617

Chemical Structure : MK-8617

CAS No.: 1187990-87-9

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MK-8617 (MK 8617, MK8617)

货号: PC-60308Not For Human Use, Lab Use Only.

MK-8617 is a potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively.

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25 mg ￥980 In stock
50 mg ￥1480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MK-8617 is a potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively.
MK-8617 shows no significant inhibition on the cytochrome p450 enzymes.
MK-8617 exhibits good oral bioavailability, causes increases in circulating reticulocytes in mice and has potential for treatment of anemia.

物理化学性质&存储条件

分子量 443.45
分子式 C24H21N5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide

参考文献

1. Debenham JS, et al. J Med Chem. 2016 Dec 22;59(24):11039-11049.

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