MK-8591 |CAS:865363-93-5 Probechem Biochemicals

Chemical Structure : MK-8591

CAS No.: 865363-93-5

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MK-8591 (Islatravir, MK8591, EFdA)

货号: PC-61817Not For Human Use, Lab Use Only.

MK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs, inhibits HIV-1 reverse transcriptase with multiple mechanisms.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2880	In stock
25 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

MK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs, inhibits HIV-1 reverse transcriptase with multiple mechanisms.
MK-8591 also retains potent activity against multinucleoside-resistant HIV-2 mutants (EC50<11 nM).

物理化学性质&存储条件

分子量	293.25
分子式	C12H12FN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol

参考文献

1. Wu VH, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00744-17.

2. Salie ZL, et al. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9274-9.

3. Michailidis E, et al. J Biol Chem. 2014 Aug 29;289(35):24533-48.

MK-8591 (Islatravir, MK8591, EFdA)

生物&药学活性

物理化学性质&存储条件

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MK-8591 (Islatravir, MK8591, EFdA)

生物&药学活性

物理化学性质&存储条件

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