MK-8325 dihydrochloride | HCV NS5A inhibitor | Probechem Biochemicals

Chemical Structure : MK-8325 dihydrochloride

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MK-8325 dihydrochloride (MK8325 dihydrochloride)

货号: PC-63304Not For Human Use, Lab Use Only.

MK-8325 dihydrochloride is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively.

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生物&药学活性

MK-8325 dihydrochloride is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively.
MK-8325 also demonstrates potencies comparable to MK-4882 against a panel of mutants in both the GT1a and GT1b backgrounds (GT1a M28V IC50=0.1 nM).
MK-8325 demonstrates no cell toxicity with a CC50 >25 uM against Huh-7 replicon cells.

物理化学性质&存储条件

分子量	915.937
分子式	C43H54Cl2F2N8O6Si
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl ((S)-1-((R)-5-(7-(4-(2-((S)-4,4-difluoro-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)phenyl)-1H-naphtho[1,2-d]imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate dihydrochloride

参考文献

1. Nair AG, et al. Bioorg Med Chem Lett. 2018 Mar 20. pii: S0960-894X(18)30242-7.

MK-8325 dihydrochloride (MK8325 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK-8325 dihydrochloride (MK8325 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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