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首页-小分子抑制剂&激动剂-GPCR-GPR119-MK-8282
MK-8282

Chemical Structure : MK-8282

CAS No.: 1147556-27-1

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MK-8282 (MK8282)

货号: PC-63460Not For Human Use, Lab Use Only.

MK-8282 is a potent, selective, oral GPR119 agonist with EC50 of 10 and 58 nM for hGPR119 and mGPR119, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MK-8282 is a potent, selective, oral GPR119 agonist with EC50 of 10 and 58 nM for hGPR119 and mGPR119, respectively.
    MK-8282 shows >150 fold selectivity over other receptors (Eurofin panlabs assay), transporters and ion channels.
    MK-8282 exhibits improved glucose tolerance in multiple animal models and has excellent off-target profile.

    物理化学性质&存储条件

    分子量 503.915
    分子式 C23H23ClFN5O5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-methylcyclopropyl (1R,5S,9r)-9-((6-((2-chloro-4-cyanophenyl)amino)-5-fluoropyrimidin-4-yl)oxy)-9-hydroxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate

    参考文献

    1. Santhosh F. Neelamkavil, et al. ACS Med. Chem. Lett. 2018. DOI: 10.1021/acsmedchemlett.8b00073.

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