MK-8267 |CAS:1146209-50-8 Probechem Biochemicals

Chemical Structure : MK-8267

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MK-8267 (SCH 2047069, MK8267)

货号: PC-62337Not For Human Use, Lab Use Only.

MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM.

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生物&药学活性

MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM.
MK-8267 inhibits a broader panel of 57 different tumor cell lines with IC50 <30 nM.
MK-8267 shows significant brain uptake in mouse and rat with brain/plasma AUC ratio of 4 in rats, demonstrates anti-tumor activities in the tumor xenograft mouse model.

物理化学性质&存储条件

分子量	439.429
分子式	C20H17F4N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(2-Aminoethyl)-5'-(2,5-difluorophenyl)-6,7-difluoro-3'H-spiro[chromane-4,2'-[1,3,4]thiadiazol]-3'-yl)ethan-1-one

参考文献

1. Mansoor UF, et al. Bioorg Med Chem. 2015 May 15;23(10):2424-34.

MK-8267 (SCH 2047069, MK8267)

生物&药学活性

物理化学性质&存储条件

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MK-8267 (SCH 2047069, MK8267)

生物&药学活性

物理化学性质&存储条件

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