MK-8245 |CAS:1030612-90-8 Probechem Biochemicals

Chemical Structure : MK-8245

CAS No.: 1030612-90-8

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MK-8245 (MK 8245;MK8245)

货号: PC-43373Not For Human Use, Lab Use Only.

MK-8245 is a potent, selective liver-targeted stearoyl-CoA desaturase (SCD) inhibitor with IC50 of 3, 3 and 1 nM for rat, mouse and human SCD1 enzyme, respectively.

规格	价格	库存
1 mg (Free Sample)	￥180	In stock
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MK-8245 is a potent, selective liver-targeted stearoyl-CoA desaturase (SCD) inhibitor with IC50 of 3, 3 and 1 nM for rat, mouse and human SCD1 enzyme, respectively.
MK-8245 displays highly selective over the Δ-5 and Δ-6 desaturases (IC50>100 uM); has IC50 values of 68 nM and 1066 nM in Hum HepG2 and rat hepatocyte assays, demonstrates HepG2/hepatocyte ratio of 16:1.
MK-8245 exhibits preclinical antidiabetic and antidyslipidemic efficacy in vivo, demonstrats maximal liver SCD inhibition while sparing inhibition in the skin and eye tissues associated with adverse events.

物理化学性质&存储条件

分子量	467.2491
分子式	C17H16BrFN6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: 19 mg/mL
Chemical Name/SMILES	2H-Tetrazole-2-acetic acid, 5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-

参考文献

1. Oballa RM, et al. J Med Chem. 2011 Jul 28;54(14):5082-96.

2. Landry F, et al. J Lipid Res. 2011 Aug;52(8):1494-9.

MK-8245 (MK 8245;MK8245)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK-8245 (MK 8245;MK8245)

生物&药学活性

物理化学性质&存储条件

参考文献

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