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Chemical Structure : MK-8242

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MK-8242 (SCH-900242;SCH 900242;MK 8242)

货号: PC-60262Not For Human Use, Lab Use Only.

A potent, orally bioavailable, small-molecule inhibitor of HDM2/p53 protein-protein interaction.

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生物&药学活性

A potent, orally bioavailable, small-molecule inhibitor of HDM2/p53 protein-protein interaction; stabilizes the tumor suppressor TP53 and induces growth arrest or apoptosis downstream of TP53 induction; has an IC50 of 70 nM for TP53 wild-type cell lines versus >10 uM for TP53 mutant cell lines.

Blood Cancer

Phase 1 Clinical

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Kang MH, et al. Pediatr Blood Cancer. 2016 Oct;63(10):1744-52.

2. Cancer Discov. 2017 May;7(5):451. doi: 10.1158/2159-8290.CD-RW2017-047.

3. Wagner AJ, et al. J Clin Oncol. 2017 Apr 20;35(12):1304-1311.

MK-8242 (SCH-900242;SCH 900242;MK 8242)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK-8242 (SCH-900242;SCH 900242;MK 8242)

生物&药学活性

物理化学性质&存储条件

参考文献

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