MK-8033 hydrochloride |CAS:1283000-43-0 Probechem Biochemicals

Chemical Structure : MK-8033 hydrochloride

CAS No.: 1283000-43-0

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MK-8033 hydrochloride (MK8033 hydrochloride;MK 8033 hydrochloride)

货号: PC-43478Not For Human Use, Lab Use Only.

MK-8033 is a potent, specific, dual c-Met/Ron kinases inhibitor with IC50 of 1/7 nM, also potently inhibits oncogenic c-Met activation loop mutants Y1230C, Y1230H and Y1235D with IC50 of 0.6-1.2 nM.

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5 mg	￥2850	In stock
25 mg	￥6850	In stock
100 mg		Get quote
500 mg		Get quote

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生物&药学活性

MK-8033 is a potent, specific, dual c-Met/Ron kinases inhibitor with IC50 of 1/7 nM, also potently inhibits oncogenic c-Met activation loop mutants Y1230C, Y1230H and Y1235D with IC50 of 0.6-1.2 nM; MK-8033 is >100-fold selective relative to Ron and c-Met inhibition against a panel of 221 kinases; potently and selectively inhibits growth in c-Met amplified cell lines (GTL-16 proliferation IC50 =582 nM), causes full inhibition of tumor growth in c-Met amplified (GTL-16) subcutaneous tumor xenograft model; synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth.

Solid Tumors

Phase 1 Clinical

物理化学性质&存储条件

分子量
分子式	C25H22ClN5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5H-Benzo[4,5]cyclohepta[1,2-b]pyridine-7-methanesulfonamide, 3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-N-(2-pyridinylmethyl)-, hydrochloride (1:1)

参考文献

1. Northrup AB, et al. J Med Chem. 2013 Mar 28;56(6):2294-310.

2. Bhardwaj V, et al. J Thorac Oncol. 2012 Aug;7(8):1211-7.

3. Marchion DC, et al. Oncol Rep. 2013 May;29(5):2011-8.

4. Keedy VL, et al. Invest New Drugs. 2018 Jan 29. doi: 10.1007/s10637-018-0567-z.

MK-8033 hydrochloride (MK8033 hydrochloride;MK 8033 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK-8033 hydrochloride (MK8033 hydrochloride;MK 8033 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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