MK-7845 | SARS-CoV-2 3CLPro inhibitor | Probechem Biochemicals

Chemical Structure : MK-7845

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MK-7845 (MK7845)

货号: PC-21803Not For Human Use, Lab Use Only.

MK-7845 is a potent, reversible covalent SARS-CoV-2 3CLPro inhibitor with IC50 of 8.7 nM, inhibits wild-type SARS-CoV-2 3CLPro in SARS-CoV-2 reporter replicon assay in A549 cells with IC50 of 15 nM.

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生物&药学活性

MK-7845 is a potent, reversible covalent SARS-CoV-2 3CLPro inhibitor with IC50 of 8.7 nM, inhibits wild-type SARS-CoV-2 3CLPro in SARS-CoV-2 reporter replicon assay in A549 cells with IC50 of 15 nM.
MK-7845 isplays 82-fold to >1000-fold selectivity agianst a panel of host-cell proteases.
MK-7845 otently inhibits P132H mutant 3CLPro present in the Omicron variant with IC50 of 15 nM.
MK-7845 hows similar activity against the parental WA1/2020, Delta, and Omicron strains of the virus with EC50 value of 215 nM-444 nM.
MK-7845 showed significant and dose-dependent reductions in viral load beginning at 250 mg/kg in mouse model of SARS-CoV-2 infection.

物理化学性质&存储条件

分子量	516.59
分子式	C24H38F2N4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl ((S)-1-((1S,3aR,6aS)-1-(((S)-6,6-difluoro-1-(methylamino)-1,2-dioxoheptan-3-yl)carbamoyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

参考文献

1. Valerie W Shurtleff, et al. J Med Chem. 2024 Feb 16. doi: 10.1021/acs.jmedchem.3c02248.

MK-7845 (MK7845)

生物&药学活性

物理化学性质&存储条件

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MK-7845 (MK7845)

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物理化学性质&存储条件

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