MK-7762 | Antitubercular | Probechem Biochemicals

Chemical Structure : MK-7762

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MK-7762 (TBD09, MK7762)

货号: PC-25987Not For Human Use, Lab Use Only.

MK-7762 (TBD09) is a new broadly active oxazolidinone Mycobacterium tuberculosis (Mtb) inhibitor with MIC95 of 0.93 uM, inhibits the mycobacterial ribosome.

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生物&药学活性

MK-7762 (TBD09) is a new broadly active oxazolidinone Mycobacterium tuberculosis (Mtb) inhibitor with MIC95 of 0.93 uM, inhibits the mycobacterial ribosome.
MK-7762 shows no inhibition in a panel of 106 off-targets except for monoamine oxidase-B (IC50=6.9 uM).
MK-7762 showsminimal inhibition of MPS (half-maximal effective concentration (EC50) of 98 µM) compared to linezolid (EC50 of 16 µM), suggesting a low risk for mitochondrial toxicity in humans compared to linezolid.
MK-7762 has a more potent minimum bactericidal concentration (MBC) than that of linezolid with an observed MBC99 of 18.1 µM compared to 52.7 µM.
MK-7762 is active against a wide range of diverse drug-sensitive and drug-resistant clinical isolates and showed similar bactericidal activity as linezolid.

物理化学性质&存储条件

分子量	419.40
分子式	C16H19F2N3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (S)-((3-(4-(1,1-dioxidothiomorpholino)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)carbamate

参考文献

1. Crowley BM, et al. Nat Med. 2026 Jan 13. doi: 10.1038/s41591-025-04164-x.

MK-7762 (TBD09, MK7762)

生物&药学活性

物理化学性质&存储条件

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MK-7762 (TBD09, MK7762)

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物理化学性质&存储条件

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