MK-7145 |CAS:1255204-84-2 Probechem Biochemicals

Chemical Structure : MK-7145

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MK-7145 (MK 7145;MK7145)

货号: PC-60460Not For Human Use, Lab Use Only.

MK-7145 is a potent, selective, and oral renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 68 nM.

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生物&药学活性

MK-7145 is a potent, selective, and oral renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 68 nM.
MK-7145 shows no significant activity on Kir family of channels and cardiac ion channels such as Cav1.2 and Nav1.5 (IC50>30 uM).
MK-7145 evokes remarkable diuresis and natriuresis in the acute rat diuresis model at 0.3 mg/kg, causes dose-dependent lowering of blood pressure in a subchronic SHR model.

物理化学性质&存储条件

分子量	466.534
分子式	C26H30N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,5'-{piperazine-1,4-diylbis[(1R)-1-hydroxyethane-2,1-diyl]}bis(4-methyl-2-benzofuran-1(3H)-one)

参考文献

1. Hampton C, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):194-206.

2. Tang H, et al. ACS Med Chem Lett. 2016 May 12;7(7):697-701.

MK-7145 (MK 7145;MK7145)

生物&药学活性

物理化学性质&存储条件

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MK-7145 (MK 7145;MK7145)

生物&药学活性

物理化学性质&存储条件

参考文献

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