MK-6169 | HCV NS5A inhibitor | Probechem Biochemicals

Chemical Structure : MK-6169

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MK-6169 (MK6169, MK 6169)

货号: PC-63367Not For Human Use, Lab Use Only.

MK-6169 is a potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 1-33 nM, retains potency against common resistance-associated substitutions in the major genotypes.

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生物&药学活性

MK-6169 is a potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 1-33 nM, retains potency against common resistance-associated substitutions in the major genotypes.
MK-6169 shows <10X shift on a majority of the genotypes and mutants tested, other than several mutants, such as GT3a Y93H and GT3a L31V.
MK-6169 also show good potency on prototypical GT1a NS3 RASs such as GT1a R155K and GT1a V36M+R155K double substitution, as well as prototypical GT1b NS3 RASs such as GT1b A156T and GT1b D168Y.
MK-6169 exhibits good pharmacokinetics in both rat and dog.

物理化学性质&存储条件

分子量	1016.203
分子式	C54H62FN9O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl ((S)-2-((S)-2-(5-((S)-6-(5-cyclopropylthiophen-2-yl)-1-fluoro-3-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-10-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-((R)-2,2-dimethyltetrahydro-2H-

参考文献

1. Yu W, et al. J Med Chem. 2018 Apr 21. doi: 10.1021/acs.jmedchem.7b01927.

MK-6169 (MK6169, MK 6169)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK-6169 (MK6169, MK 6169)

生物&药学活性

物理化学性质&存储条件

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