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首页-小分子抑制剂&激动剂-Immunology/Inflammation-FLAP-MK-591
MK-591

Chemical Structure : MK-591

CAS No.: 147030-01-1

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MK-591 (Quiflapon sodium;MK-0591;L-686708)

货号: PC-45853Not For Human Use, Lab Use Only.

Quiflapon (MK-591, MK-0591, L-686708) sodium is a potent, orally active leukotriene biosynthesis inhibitor that acts by inhibiting 5-lipoxygenase activating protein (FLAP) with IC50 of 1.6 nM in a FLAP binding assay.

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5 mg ￥1180 In stock
10 mg ￥1780 In stock
25 mg ￥2980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Quiflapon (MK-591, MK-0591, L-686708) sodium is a potent, orally active leukotriene biosynthesis inhibitor that acts by inhibiting 5-lipoxygenase activating protein (FLAP) with IC50 of 1.6 nM in a FLAP binding assay.
Quiflapon (MK-591) inhibits leukotriene (LT) biosynthesis in intact human and elicited rat PMNLs with IC50 of 3.1 nM and 6.1 nM, respectively.
Quiflapon (MK-591) inhibits the systemic generation of peptidoleukotrienes as measured by urinary LTE4 excretion in dogs (ED50=1 mg/kg).

物理化学性质&存储条件

分子量 609.1531
分子式 C34H34ClN2NaO3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(2-quinolinylmethoxy)-, sodium salt (1:1)

参考文献

1. Brideau C, et al. Can J Physiol Pharmacol. 1992 Jun;70(6):799-807.

2. Ménard L, et al. Can J Physiol Pharmacol. 1992 Jun;70(6):808-13.

3. Tagari P, et al. J Pharmacol Exp Ther. 1993 Apr;265(1):416-25.

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