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首页-小分子抑制剂&激动剂-GPCR-Leukotriene Receptor-MK-571 sodium salt
MK-571 sodium salt

Chemical Structure : MK-571 sodium salt

CAS No.: 115103-85-0

MK-571 sodium salt (L-660711 sodium salt, MK571)

货号: PC-45775Not For Human Use, Lab Use Only.

MK-571 sodium is a potent and specific LTD4 receptor antagonist with Ki of 0.22 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MK-571 sodium is a potent and specific LTD4 receptor antagonist with Ki of 0.22 nM.
MK-571 sodium effectively blocks LTD4 activation of recombinant human and mouse CysLT1 receptors.
MK-571 sodium also is an inhibitor of multidrug resistance protein-1 (MRP1) mediated transportorally active.

物理化学性质&存储条件

分子量 537.069
分子式 C26H26ClN2NaO3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

H2O: 50 mM in H2O (26.85 mg/mL, ultrasonic needed)

Chemical Name/SMILES

Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-, sodium salt, (E)- (9CI)

参考文献

1. Gauthier JY, et al. J Med Chem. 1990 Oct;33(10):2841-5.

2. Vellenga E, et al. Br J Pharmacol. 1999 May;127(2):441-8.

3. Lynch K, et al. Nature. 1999 Jun 24;399(6738):789-93.

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