MK-4256 | SSTR3 antagonist | Probechem Biochemicals

Chemical Structure : MK-4256

加入收藏

MK-4256 (MK 4256;MK4256)

货号: PC-61088Not For Human Use, Lab Use Only.

MK-4256 is a potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 0.66 nM, >500-fold selectivity over SSTR1/2/4/5.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MK-4256 is a potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 0.66 nM, >500-fold selectivity over SSTR1/2/4/5.
MK-4256 reduces glucose excursion in a dose-dependent fashion with maximal efficacy achieved at doses as low as 0.03 mg/kg po, with minimal hypoglycemia risk.
Preclinical tirals of MK-4256 are discontinued due to dose-dependent QTc in conscious cardiovascular (CV) dog model.

物理化学性质&存储条件

分子量	494.534
分子式	C27H23FN8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((1R,3R)-3-(5-(4-fluorophenyl)-1H-imidazol-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-5-methyl-1,2,4-oxadiazole

参考文献

1. He S, et al. ACS Med Chem Lett. 2012 May 7;3(6):484-9.

2. He S, et al. ACS Med Chem Lett. 2014 Apr 21;5(7):748-53.

3. He S, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1529-1535.

MK-4256 (MK 4256;MK4256)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MK-4256 (MK 4256;MK4256)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.