Chemical Structure : MK-4166
CAS No.:
货号: PC-Ab1069Not For Human Use, Lab Use Only.
MK-4166 is a humanized IgG1 agonist monoclonal antibody targeting GITR. MK-4166 decreased induction and suppressive effects of T regs in vitro In human TIL cultures, MK-4166 induced phosphorylation of NFκB and increased expression of dual specificity phosphatase 6 (DUSP6), indicating that MK-4166 activated downstream NFκB and Erk signaling pathways..
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1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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MK-4166 is a humanized IgG1 agonist monoclonal antibody targeting GITR. MK-4166 decreased induction and suppressive effects of T regs in vitro In human TIL cultures, MK-4166 induced phosphorylation of NFκB and increased expression of dual specificity phosphatase 6 (DUSP6), indicating that MK-4166 activated downstream NFκB and Erk signaling pathways.
分子量 | ||
分子式 | Human IgG1-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Anti-Human GITR; human activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein; human TNFRSF18; MK-4166 |
1. 1, Mahne AE, et al. Cancer Res. 2017 Mar 1;77(5):1108-1118. 2, Sukumar S, et al. Cancer Res. 2017 Aug 15;77(16):4378-4388. 3, Papadopoulos KP, et al. Clin Cancer Res. 2021 Apr 1;27(7):1904-1911.
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