MK-4101 |CAS:935273-79-3 Probechem Biochemicals

Chemical Structure : MK-4101

CAS No.: 935273-79-3

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MK-4101 (MK 4101;MK4101)

货号: PC-42045Not For Human Use, Lab Use Only.

MK-4101 is a potent, orally bioavailable and brain penetrating Hedgehog pathway (Hh) inhibitor that inhibits Smoothened (Smo) with IC50 of 1.1 uM.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

MK-4101 is a potent, orally bioavailable and brain penetrating Hedgehog pathway (Hh) inhibitor that inhibits Smoothened (Smo) with IC50 of 1.1 uM.
MK-4101 inhibits Hh signaling in a reporter gene assay in cancer cells with IC50 of 1-1.5 uM, also inhibited the proliferation of medulloblastoma cells derived from neonatally irradiated Ptch1−/+ mice in vitro with IC50 of 0.3 uM.
MK-4101 demonstrate a robust antitumor activity against Hh-driven tumors in vivo, shows potentiation for the treatment of medulloblastoma and BCC.

物理化学性质&存储条件

分子量	493.4723
分子式	C24H24F5N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2,4-Oxadiazole, 5-(3,3-difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-

参考文献

1. Filocamo G, et al. Mol Cancer Ther. 2016 Jun;15(6):1177-89.

MK-4101 (MK 4101;MK4101)

生物&药学活性

物理化学性质&存储条件

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MK-4101 (MK 4101;MK4101)

生物&药学活性

物理化学性质&存储条件

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