MK-4074 sodium salt |CAS:1039758-18-3 Probechem Biochemicals

Chemical Structure : MK-4074 sodium salt

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MK-4074 sodium salt

货号: PC-61206Not For Human Use, Lab Use Only.

MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM.

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100 mg		Get quote
500 mg		Get quote
1 g		Get quote

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生物&药学活性

MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM; lowers lipogenesis, increases ketones and reduces liver triglycerides, increases plasma triglycerides in mice; significantly decreases de novo lipogenesis (DNL) in a dose-dependent manner with ID50 of 0.9 mg/kg in models of obesity, type 2 diabetes and fatty liver.

Steatohepatitis

Phase 1 Clinical

物理化学性质&存储条件

分子量	587.608
分子式	C33H30N3NaO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(1'-(1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carbonyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)nicotinic acid, sodium salt

参考文献

1. Kim CW, et al. Cell Metab. 2017 Aug 1;26(2):394-406.e6.