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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-AMPK-MK-3903
MK-3903

Chemical Structure : MK-3903

CAS No.: 1219737-12-8

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MK-3903 (MK3903)

货号: PC-62013Not For Human Use, Lab Use Only.

MK-3903 is a potent and selective, direct and oral AMPK activator with EC50 of 9 nM.

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10 mg ￥1380 In stock
25 mg ￥2180 In stock
50 mg ￥3680 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MK-3903 is a potent and selective, direct and oral AMPK activator with EC50 of 9 nM.
MK-3903 activates 10 of the 12 phosphorylated AMPK (pAMPK) complexes with EC50s of 8-40 nM.
MK-3903 improves lipid metabolism and insulin sensitization in mice.

物理化学性质&存储条件

分子量 454.91
分子式 C27H19ClN2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 100 mM (45.5 mg/mL)
Chemical Name/SMILES

5-[(5-[1,1'-Biphenyl]-4-yl-6-chloro-1H-benzimidazol-2-yl)oxy]-2-methylbenzoic acid

参考文献

1. Lan P, et al. J Med Chem. 2017 Nov 9;60(21):9040-9052.

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