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首页-小分子抑制剂&激动剂-GPCR-Prostaglandin Receptor-MK-2894
MK-2894

Chemical Structure : MK-2894

CAS No.: 1006036-87-8

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MK-2894 (MK 2894, MK2894)

货号: PC-42572Not For Human Use, Lab Use Only.

MK-2894 (MK2894) is a highly potent, selective, second generation prostaglandin E2 subtype 4 receptor (EP4) antagonist with Ki of 0.56 nM.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3680 In stock
50 mg ￥5580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MK-2894 (MK2894) is a highly potent, selective, second generation prostaglandin E2 subtype 4 receptor (EP4) antagonist with Ki of 0.56 nM.
MK-2894 displays >10,000-fold selectivity over EP2 receptors.
MK-2894 exhibits favorable pharmacokinetic profile and potent anti-inflammatory activity in animal models of pain/inflammation.

物理化学性质&存储条件

分子量 473.5073
分子式 C25H22F3NO3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzoic acid, 4-[1-[[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]-

参考文献

1. Blouin M, et al. J Med Chem. 2010 Mar 11;53(5):2227-38.

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