MK-2305 | GPR40 agonist | Probechem Biochemicals

Chemical Structure : MK-2305

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MK-2305 (MK2305, MK 2305)

货号: PC-20434Not For Human Use, Lab Use Only.

MK-2305 (MK2305) is a potent and selective partial GPR40 (FFAR1) agonist with EC50 of 6 nM (rat GPR40), stimulates glucose stimulated insulin secretion (GSIS).

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生物&药学活性

MK-2305 (MK2305) is a potent and selective partial GPR40 (FFAR1) agonist with EC50 of 6 nM (rat GPR40), stimulates glucose stimulated insulin secretion (GSIS).
MK-2305 binds to the same site as other GPR40 partial agonists such as AMG837 (Cat. PC-43813) and TAK-875 (Cat. PC-42610).
MK-2305 displays >2,000-fold selectivity over GPR120 (FFA4), GPR41 (FFA3), GPR43 (FFA2), PPARα, PPARδ, PPARγ.
MK-2305 acutely improved glucose tolerance and GSIS, significantly decreased AUC at doses between 10-0.3 mg/kg (by 54% to 18%, respectively).
MK-2305 (30 mg/kg) lowerd fasting and fed glucose following chronic administration.

物理化学性质&存储条件

分子量	443.82
分子式	C19H13ClF3NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(7-(2-chloro-4-(trifluoromethyl)phenoxy)chroman-4-yl)thiazolidine-2,4-dione

参考文献

1. Miller C, et al. PLoS One. 2017 May 23;12(5):e0176182.

2. Hauge M, et al. Mol Metab. 2015;4: 3–14. 10.1016/j.molmet.2014.10.002

MK-2305 (MK2305, MK 2305)

生物&药学活性

物理化学性质&存储条件

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MK-2305 (MK2305, MK 2305)

生物&药学活性

物理化学性质&存储条件

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