MK-2206 dihydrochloride | Akt inhibitor | Probechem Biochemicals

Chemical Structure : MK-2206 dihydrochloride

CAS No.: 1032350-13-2

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MK-2206 dihydrochloride (MK2206 dihydrochloride)

货号: PC-42551Not For Human Use, Lab Use Only.

MK-2206 dihydrochloride is a potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

MK-2206 dihydrochloride is a potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively.
MK-2206 shows 5-fold less potent against human Akt3 (IC50=65 nM).
MK-2206 synergistically inhibits cell proliferation of human cancer cell lines in combination with erlotinib or lapatinib in vitro.
MK-2206 suppresses the Akt phosphorylation that is induced by carboplatin and gemcitabine.

物理化学性质&存储条件

分子量	480.389
分子式	C25H23Cl2N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO
Chemical Name/SMILES	1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-, hydrochloride (1:2)

参考文献

1. Hirai H, et al. Mol Cancer Ther. 2010 Jul;9(7):1956-67.

2. Cheng Y, et al. Mol Cancer Ther. 2012 Jan;11(1):154-64.

3. Whicker ME, et al. BMC Cancer. 2016 Jul 27;16:550.

MK-2206 dihydrochloride (MK2206 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK-2206 dihydrochloride (MK2206 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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