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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-Akt-MK-2206
MK-2206

Chemical Structure : MK-2206

CAS No.: 1032349-77-1

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MK-2206 (MK2206)

货号: PC-26053Not For Human Use, Lab Use Only.

MK-2206 is a potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively.

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5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MK-2206 is a potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively.
MK-2206 shows 5-fold less potent against human Akt3 (IC50=65 nM).
MK-2206 synergistically inhibits cell proliferation of human cancer cell lines in combination with erlotinib or lapatinib in vitro.
MK-2206 suppresses the Akt phosphorylation that is induced by carboplatin and gemcitabine.

物理化学性质&存储条件

分子量 443.94
分子式 C25H22ClN5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-(4-(1-Aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one hydrochloride

参考文献

1. Hirai H, et al. Mol Cancer Ther. 2010 Jul;9(7):1956-67.

2. Cheng Y, et al. Mol Cancer Ther. 2012 Jan;11(1):154-64.

3. Whicker ME, et al. BMC Cancer. 2016 Jul 27;16:550.

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