MK-1925 |CAS:932705-04-9 Probechem Biochemicals

Chemical Structure : MK-1925

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MK-1925 (MK1925)

货号: PC-61588Not For Human Use, Lab Use Only.

MK-1925 is a selective, orally active, brain-penetrant opioid receptor-like 1 (ORL1.

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生物&药学活性

MK-1925 is a selective, orally active, brain-penetrant opioid receptor-like 1 (ORL1, NOP receptor) antagonist with binding IC50 of 8.2 nM.
MK-1925 shows good selectivity over other opioid receptors and the hERG channel.
MK-1925 exhibits in vivo antagonist activity against the reduction in locomotor activity induced by ORL1 agonist in mice.

物理化学性质&存储条件

分子量	362.4
分子式	C19H21F3N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[5-(3,5-difluorophenyl)-3-({[(1S,3R)-3-fluorocyclopentyl]amino}methyl)-4-methyl-1H-pyrazol-1-yl]propanenitrile

参考文献

1. Kobayashi K, et al. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4729-32.

MK-1925 (MK1925)

生物&药学活性

物理化学性质&存储条件

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MK-1925 (MK1925)

生物&药学活性

物理化学性质&存储条件

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