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首页-小分子抑制剂&激动剂-GPCR-GPR109A (Niacin Receptor 1)-MK-1903
MK-1903

Chemical Structure : MK-1903

CAS No.: 1268882-43-4

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MK-1903 (MK1903)

货号: PC-21427Not For Human Use, Lab Use Only.

MK-1903 is potent and selective agonist of GPR109a with EC50 of 12.9 nM, Emax 102%.

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5 mg ￥980 In stock
10 mg ￥1580 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MK-1903 is potent and selective agonist of GPR109a with EC50 of 12.9 nM, Emax 102%.
MK-1903 exhibits no inhibition or binding against a standard panel of GPCRs and ion channels (PanLabs).
MK-1903 is more potent than niacin in the cell based assays.
MK-1903 induces robust decrease in plasma free fatty acids and produces the expected flush response in vivo.

物理化学性质&存储条件

分子量 164.16
分子式 C8H8N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4aR,5aR)-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxylic acid

参考文献

1. Boatman PD, et al. J Med Chem. 2012 Apr 26;55(8):3644-66.

2. Brett Lauring, et al. Sci Transl Med. 2012 Aug 22;4(148):148ra115.

3. Viatchenko-Karpinski V, et al. Glia. 2022 Apr;70(4):634-649.

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