MK-1832 |CAS:935868-50-1 Probechem Biochemicals

首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-MK-1832

Chemical Structure : MK-1832

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MK-1832 (MK1832)

货号: PC-62815Not For Human Use, Lab Use Only.

MK-1832 is a potent, selective Kv1.5 inhibitor with IC50 of 86 nM, exhibits improved selectivity for IKur over IKs (>3000-fold) compares with MK-0448 (70-fold).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MK-1832 is a potent, selective Kv1.5 inhibitor with IC50 of 86 nM, exhibits improved selectivity for IKur over IKs (>3000-fold) compares with MK-0448 (70-fold).
MK-1832 also exhibits an improved preclinical pharmacokinetic profile.
MK-1832 is a P-gp substrate and exhibits limited CNS exposure in vivo.

物理化学性质&存储条件

分子量	422.309
分子式	C23H17Cl2N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(2-(3,5-dichlorophenyl)pyridin-3-yl)-2,2-di(pyridin-3-yl)ethan-1-ol

参考文献

1. Wolkenberg SE, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1062-1069.

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MK-1832 (MK1832)

生物&药学活性

物理化学性质&存储条件

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MK-1832 (MK1832)

生物&药学活性

物理化学性质&存储条件

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