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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Renin-MK-1597
MK-1597

Chemical Structure : MK-1597

CAS No.: 1007392-69-9

MK-1597 (ACT178882, ACT-178882, MK1597)

货号: PC-27070Not For Human Use, Lab Use Only.

MK-1597 (ACT-178882) is a potent, direct renin inhibitor with IC50 of 1.4 nM, demonstrates blood pressure lowering properties.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MK-1597 (ACT-178882) is a potent, direct renin inhibitor with IC50 of 1.4 nM, demonstrates blood pressure lowering properties.

物理化学性质&存储条件

分子量 647.03
分子式 C33H38Cl3N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3R,4S)-N-(2-Chloro-5-(2-methoxyethyl)benzyl)-N-cyclopropyl-4-(6-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)pyridin-3-yl)piperidine-3-carboxamide

参考文献

1. Corminboeuf O, et al. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6291-6.

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