MK-1256 | Cathepsin K inhibitor | Probechem Biochemicals

Chemical Structure : MK-1256

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MK-1256 (MK1256)

货号: PC-49223Not For Human Use, Lab Use Only.

MK-1256 (MK1256) is a potent, selective cathepsin K (Cat K) inhibitor with IC50 of 0.62 nM, >1100-fold selectivity over Cat B, L, S, C, H, Z, and V, 110-fold over Cat F.

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生物&药学活性

MK-1256 (MK1256) is a potent, selective cathepsin K (Cat K) inhibitor with IC50 of 0.62 nM, >1100-fold selectivity over Cat B, L, S, C, H, Z, and V, 110-fold over Cat F.
MK-1256 is efficacious in monkey model of osteoporosis.

物理化学性质&存储条件

分子量	563.417
分子式	C23H23Cl2F3N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R)-5,5-Dichloro-N-(1-cyanocyclopropyl)-2-[4-[4-(methylsulfonyl)phenyl]-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]cyclohexanecarboxamide

参考文献

1. Robichaud J, et al. J Med Chem. 2008 Oct 23;51(20):6410-20.

2. Ma B, et al. Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr;390(4):435-441.

MK-1256 (MK1256)

生物&药学活性

物理化学性质&存储条件

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MK-1256 (MK1256)

生物&药学活性

物理化学性质&存储条件

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