MK-0941 | Glucokinase activator | Probechem Biochemicals

Chemical Structure : MK-0941

CAS No.: 752240-01-0

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MK-0941 (MK0941)

货号: PC-61878Not For Human Use, Lab Use Only.

MK-0941 (MK0941) is a potent, orally active Glucokinase (GK) activator with EC50 of 0.240 and 0.065 uM in 2.5 and 10 mM glucose, respectively.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3580	In stock
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100 mg		Get quote

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生物&药学活性

MK-0941 (MK0941) is a potent, orally active Glucokinase (GK) activator with EC50 of 0.240 and 0.065 uM in 2.5 and 10 mM glucose, respectively.
MK-0941 increases insulin secretion by 17-fold and glucose uptake up to 18-fold, respectively, in isolated rat islets of Langerhans and hepatocytes at 10 uM。
MK-0941 exhibits strong glucose-lowering activity in rodent models of type 2 diabetes and healthy dogs.

物理化学性质&存储条件

分子量	460.5
分子式	C21H24N4O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[[6-(ethylsulfonyl)-3-pyridinyl]oxy]-5-[(1S)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

参考文献

1. Eiki J, et al. Mol Pharmacol. 2011 Dec;80(6):1156-65.

2. Meininger GE, et al. Diabetes Care. 2011 Dec;34(12):2560-6.

MK-0941 (MK0941)

生物&药学活性

物理化学性质&存储条件

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MK-0941 (MK0941)

生物&药学活性

物理化学性质&存储条件

参考文献

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